福建36选7几时开奖时间: 福建36选7第18123期

通過治療僵尸細胞 有望延緩人體衰老進程

時間:2019-06-04 22:38來源:互聯網 提供網友:nan   字體: [ ]

福建36选7第18123期 www.pysue.com  ‘Zombie Cells’: Researchers Fight Aging Process of the Human Body

Creatures that refuse to die, commonly known as zombies, have appeared in popular movies and television shows for years.

Recent research has shown that an unusual part of real human biology possesses zombie-like qualities: a special kind of cells.

Like the stars of many scary stories, these so-called ‘zombie cells’ also refuse to die. Studies suggest that, as they build up in your body, they lead to aging and the conditions that come with that process, like bone and brain diseases.

Now, researchers are studying drugs that can kill zombie cells and possibly treat the problems they bring.

James Kirkland is a medical doctor and aging specialist with the Mayo Clinic in Rochester, Minnesota. He is working on the research. He told the Associated Press that, generally, the goal is to fight aging itself. This in turn may delay the appearance of some age-related disease and disabilities.

The research has been done mainly in mice. Earlier this year, the first test on people was published and provided some interesting results.

Zombie cells are actually called senescent cells. They start out like usual cells, but then face problems, like viral infection or damage to their genetic1 material (DNA). At that point, a cell may die or become a zombie cell – entering a state of suspended animation2.

These zombie cells release chemicals that can harm nearby normal cells. That is where the trouble starts.

What kind of trouble? In studies on mice, drugs that destroy zombie cells — called senolytics — have been shown to improve many different conditions. This includes cataracts3, diabetes4, enlargement of the heart, kidney problems, and age-related muscle loss.

Mouse studies have also shown a more direct tie between zombie cells and aging. When drugs targeting those cells were given to older mice, the animals showed improved walking speed, strength and an ability to continue physical activity. Even when researchers used the treatment on very old mice, it extended their lifespan by about 36 percent.

Researchers have also shown that putting zombie cells into young mice generally made them act older. Their walking speed slowed down. Their muscle strength and ability to stay active also decreased. Tests showed the newly added cells changed other cells into the zombie state.

This year, Kirkland and his team published the first study of a zombie-cell treatment in people. It involved 14 patients with idiopathic pulmonary fibrosis, an often deadly lung disease. Risk of the disease rises with age, and patients’ lungs show evidence of zombie cells.

After three weeks of treatment, patients who took part in the experiment improved on some measures of physical health, like walking speed. Other measures did not show improvement.

Gregory Cosgrove is a doctor and chief medical officer of the Pulmonary Fibrosis Foundation. He was not involved in the study. He noted5 that, overall, the results are a good sign.

“It really raises enthusiasm to proceed with the more rigorous studies,” Cosgrove said.

The field of zombie cell research is still young. But Kirkland estimates at least 12 companies have formed or launched efforts to study treatments.

Laura Niedernhofer is a professor of biochemistry at the University of Minnesota in Minneapolis. She suggested that, in addition to age-related diseases, anti-zombie cell drugs might be useful for treating early aging among cancer survivors6. This condition brings on the early appearance of some diseases.

Niedernhofer said the goal is not to prevent damaged cells from turning into zombies, because they may become cancerous instead. The aim is to kill cells that have already changed, or to limit the harm they do.

And what about giving them to healthy people who want to prevent aging? That is possible but a long way off, after studies have established that the drugs are safe enough, Niedernhofer said.

Kirkland added, “We may not get there.”

In any case, experts do support the research so far. George Kuchel, a doctor with the University of Connecticut Center on Aging in Farmington, found the results very interesting.

Nir Barzilai is a researcher of aging at the Albert Einstein College of Medicine in New York. He believes treating zombie cells will play a part in the overall effort to delay, stop and maybe even undo7 aging.

I’m Bryan Lynn.

Words in This Story

mice – n. very small animals that have pointed8 noses and long, thin tails

suspended animation – n. a state in which the processes of the body, such as blood circulation, stop or become very slow for a period of time while a person or animal is unconscious

cataract(s) – n. a condition in which a part of your eye called the lens becomes cloudy and you cannot see well

diabetes – n. a serious disease in which the body cannot properly control the amount of sugar in your blood because it does not have enough insulin

enthusiasm – n. a strong feeling of active interest in something that you like or enjoy

rigorous – adj. done carefully and with a lot of attention to detail


1 genetic PgIxp     
  • It's very difficult to treat genetic diseases.遺傳性疾病治療起來很困難。
  • Each daughter cell can receive a full complement of the genetic information.每個子細胞可以收到遺傳信息的一個完全補償物。
2 animation UMdyv     
  • They are full of animation as they talked about their childhood.當他們談及童年的往事時都非常興奮。
  • The animation of China made a great progress.中國的卡通片制作取得很大發展。
3 cataracts a219fc2c9b1a7afeeb9c811d4d48060a     
n.大瀑布( cataract的名詞復數 );白內障
  • The rotor cataracts water over the top of the machines. 回轉輪將水從機器頂上注入。 來自《現代英漢綜合大詞典》
  • Cataracts of rain flooded the streets. 傾盆大雨弄得街道淹水。 來自辭典例句
4 diabetes uPnzu     
  • In case of diabetes, physicians advise against the use of sugar.對于糖尿病患者,醫生告誡他們不要吃糖。
  • Diabetes is caused by a fault in the insulin production of the body.糖尿病是由體內胰島素分泌失調引起的。
5 noted 5n4zXc     
  • The local hotel is noted for its good table.當地的那家酒店以餐食精美而著稱。
  • Jim is noted for arriving late for work.吉姆上班遲到出了名。
6 survivors 02ddbdca4c6dba0b46d9d823ed2b4b62     
幸存者,殘存者,生還者( survivor的名詞復數 )
  • The survivors were adrift in a lifeboat for six days. 幸存者在救生艇上漂流了六天。
  • survivors clinging to a raft 緊緊抓住救生筏的幸存者
7 undo Ok5wj     
  • His pride will undo him some day.他的傲慢總有一天會毀了他。
  • I managed secretly to undo a corner of the parcel.我悄悄地設法解開了包裹的一角。
8 pointed Il8zB4     
  • He gave me a very sharp pointed pencil.他給我一支削得非常尖的鉛筆。
  • She wished to show Mrs.John Dashwood by this pointed invitation to her brother.她想通過對達茨伍德夫人提出直截了當的邀請向她的哥哥表示出來。
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